HCID 117839986, compound → HCID 117839488, compound

HRID 1477660Notes

Reaction equation

HRID 1477660 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9]2)=[CH:4][CH:3]=1>[Pd].C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9]2)=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 117839986HCID 117839986, compound

Product 1

HCID 117839488HCID 117839488, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To an ethanol solution (2.6 mL) of 1-(4-fluorophenyl)-3-nitro-1H-pyrrole (131 mg, 0.635 mmol) synthesized in Reference Synthesis Example 248, palladium-activated carbon (13.1 mg) was added and the resultant mixture was stirred under hydrogen atmosphere at room temperature for 1 day. After completion of the reaction, the reaction solution was filtered with Celite and the filtrate was concentrated under reduced pressure to obtain the title compound as a crude product.

Workup

  1. additionwas added
  2. customAfter completion of the reaction
  3. filtrationthe reaction solution was filtered with Celite
  4. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-ef133aff2198447898ac518a33a8c7ac
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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