1,1'-Carbonyldiimidazole → HCID 140668416, compound

HRID 1477667Notes

Reaction equation

HRID 1477667 reaction equation
S(O)(O)(=O)=O.[CH3:6][S:7][C:8](=[NH:10])[NH2:9].[C:11](N1C=CN=C1)([N:13]1[CH:17]=[CH:16][N:15]=[CH:14]1)=[O:12]>[OH-].[Na+]>[N:13]1([C:11]([NH:10][C:8]([S:7][CH3:6])=[NH:9])=[O:12])[CH:17]=[CH:16][N:15]=[CH:14]1

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 752702-Methyl-2-thiopseudourea sulfate

Product 1

HCID 140668416HCID 140668416, compoundYield 142.8%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

To S-methylisothiourea sulfate (8.35 g, 30.0 mmol), 1 M sodium hydroxide aqueous solution (60 mL) was added and then 1,1′-carbonyldiimidazole (9.73 g, 60.0 mmol) was slowly added at 0° C. with stirring, followed by stirring the resultant mixture at 0° C. for 30 minutes. After completion of the reaction, the precipitated solid was collected by filtration and the obtained solid was washed with ice water and dried to obtain the title compound (7.89 g, yield 72%).

Workup

  1. customAfter completion of the reaction
  2. filtrationthe precipitated solid was collected by filtration
  3. washthe obtained solid was washed with ice water
  4. customdried

Sources & evidence

ORD record
ord-ce4e51567b224aa299c83c9c34423a79
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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