Ethyl orthoformate → HCID 117839443, compound

HRID 1477669Notes

Reaction equation

HRID 1477669 reaction equation
[Br:1][C:2]1[S:6][C:5]([CH2:7][NH:8][C:9]([NH:11][C:12]([S:14][CH3:15])=[NH:13])=[O:10])=[CH:4][CH:3]=1.[CH:16](OCC)(OCC)OCC>>[Br:1][C:2]1[S:6][C:5]([CH2:7][N:8]2[CH:16]=[N:13][C:12]([S:14][CH3:15])=[N:11][C:9]2=[O:10])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 31214Ethyl orthoformateHCID 140668404HCID 140668404, compound

Product 1

HCID 117839443HCID 117839443, compoundYield 76%

Procedure

Methyl N-({[(5-bromothiophen-2-yl)methyl]amino}carbonyl)-carbamimidothioate (700 mg, 2.27 mmol) synthesized in Reference Synthesis Example 295 and triethyl orthoformate were used to obtain the title compound (547 mg, yield 76%) by synthesis in a similar manner to Reference Synthesis Example 292.

Sources & evidence

ORD record
ord-104fb0f4ef884b2d95f6adc374babdf1
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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