tert-Butyl piperazine-1-carboxylate → HCID 117849156, compound

HRID 1477683Notes

Reaction equation

HRID 1477683 reaction equation
[CH3:1][C:2]1[N:7]([CH2:8][C:9]2[S:10][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:13]=2)[C:6](=[O:18])[N:5]=[C:4](SC)[N:3]=1.[N:21]1([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[CH3:1][C:2]1[N:7]([CH2:8][C:9]2[S:10][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:13]=2)[C:6](=[O:18])[N:5]=[C:4]([N:24]2[CH2:23][CH2:22][N:21]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:26][CH2:25]2)[N:3]=1

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 117839530HCID 117839530, compound

Product 1

HCID 117849156HCID 117849156, compoundYield 97.1%

Procedure

6-Methyl-4-(methylthio)-1-{[5-(trifluoromethyl)thiophen-2-yl]methyl}-1,3,5-triazin-2(1H)-one (309 mg, 0.962 mmol) synthesized in Reference Synthesis Example 292 and tert-butyl piperazine-1-carboxylate (269 mg, 1.44 mmol) were used to obtain the title compound (429 mg, yield 97%) by synthesis in a similar manner to Reference Synthesis Example 348.

Sources & evidence

ORD record
ord-2fcf709f23424c38b53998b0650bc372
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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