Trifluoroacetic acid → HCID 117839674, compound

HRID 1477686Notes

Reaction equation

HRID 1477686 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([CH2:19][O:20][CH2:21][O:22][CH3:23])([CH2:14][O:15][CH2:16][O:17][CH3:18])[CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH:9]=2)=[CH:4][CH:3]=1.[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34]>ClCCl>[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34].[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:13]([CH2:19][O:20][CH2:21][O:22][CH3:23])([CH2:14][O:15][CH2:16][O:17][CH3:18])[CH2:12][NH:11][CH2:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117848946HCID 117848946, compound

Product 1

HCID 117839674HCID 117839674, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a dichloromethane solution (0.80 mL) of tert-butyl 4-(4-fluorophenyl)-5,5-bis[(methoxymethoxy)methyl]-5,6-dihydropyridine-1(2H)-carboxylate (40.0 mg, 0.0940 mmol) synthesized in Reference Synthesis Example 358, trifluoroacetic acid (40.0 μL, 0.538 mmol) was added at room temperature and the resultant mixture was stirred for 1 day. After completion of the reaction, the reaction solution was concentrated under reduced pressure to obtain a crude product of the title compound.

Workup

  1. additionwas added at room temperature
  2. customAfter completion of the reaction
  3. concentrationthe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-eb4eb04b32d345fc84e23e4a352c15f3
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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