Lithium hydroxide, monohydrate → HCID 117849005, compound

HRID 1477688Notes

Reaction equation

HRID 1477688 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C@@H:13]([O:14]C(=O)C(C)(C)C)[CH2:12][N:11]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:10][CH:9]=2)=[CH:4][CH:3]=1.O.[OH-].[Li+]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C@@H:13]([OH:14])[CH2:12][N:11]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 117849010HCID 117849010, compound

Product 1

HCID 117849005HCID 117849005, compound

Procedure

To a 1,4-dioxane (500 μL)-water (100 μL) solution of tert-butyl (R)-4-(4-fluorophenyl)-5-(pivaloyloxy)-5,6-dihydropyridine-1(2H)-carboxylate (50.0 mg, 0.132 mmol) synthesized in Reference Synthesis Example 131, lithium hydroxide monohydrate (17.0 mg, 0.405 mmol) was added and the resultant mixture was stirred at 115° C. for 10 hours. After completion of the reaction, the reaction solution was analyzed with chiral column chromatography to measure optical purity.

Workup

  1. additionwas added
  2. customAfter completion of the reaction

Sources & evidence

ORD record
ord-dee2216e1d0643f281ea101bb7e13f6c
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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