Lithium hydroxide, monohydrate → HCID 117849063, compound

HRID 1477689Notes

Reaction equation

HRID 1477689 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C@H:13]([O:14]C(=O)C(C)(C)C)[CH2:12][N:11]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:10][CH:9]=2)=[CH:4][CH:3]=1.O.[OH-].[Li+]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C@H:13]([OH:14])[CH2:12][N:11]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 117849117HCID 117849117, compound

Product 1

HCID 117849063HCID 117849063, compound

Procedure

To a 1,4-dioxane (500 μL)-water (100 μL) solution of tert-butyl (S)-4-(4-fluorophenyl)-5-(pivaloyloxy)-5,6-dihydropyridine-1(2H)-carboxylate (50.0 mg, 0.132 mmol) synthesized in Reference Synthesis Example 136, lithium hydroxide monohydrate (17.0 mg, 0.405 mmol) was added and the resultant mixture was stirred at 115° C. for 10 hours. After completion of the reaction, the reaction solution was analyzed with chiral column chromatography to measure optical purity.

Workup

  1. additionwas added
  2. customAfter completion of the reaction

Sources & evidence

ORD record
ord-ec615e791eed44a2add116515f3b22aa
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

Loading…