Tetrahydro-4H-pyran-4-one → HCID 117925680, compound

HRID 1477703Notes

Reaction equation

HRID 1477703 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][N:7]2[CH:12]=[N:11][C:10]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)=[N:9][C:8]2=[O:19])=[CH:4][CH:3]=1.[O:22]1[CH2:27][CH2:26][C:25](=O)[CH2:24][CH2:23]1>>[Cl:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][N:7]2[CH:12]=[N:11][C:10]([N:13]3[CH2:18][CH2:17][N:16]([CH:25]4[CH2:26][CH2:27][O:22][CH2:23][CH2:24]4)[CH2:15][CH2:14]3)=[N:9][C:8]2=[O:19])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 121599Tetrahydro-4H-pyran-4-oneHCID 117839396HCID 117839396, compound

Product 1

HCID 117925680HCID 117925680, compoundYield 6.7%

Procedure

The synthesis was performed using 1-(4-chlorobenzyl)-4-(piperazin-1-yl)-1,3,5-triazin-2(1H)-one (31 mg, 0.10 mmol) synthesized in Reference Synthesis Example 9 and dihydro-2H-pyran-4(3H)-one (10 mg, 0.10 mmol) in a similar manner to Synthesis Example 72 to obtain the title compound (2.6 mg, yield: 6.6%).

Sources & evidence

ORD record
ord-882aa46a8d404108bd072c22e0668bf7
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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