2-Chloro-5-(trifluoromethyl)pyridine → HCID 117839830, compound

HRID 1477706Notes

Reaction equation

HRID 1477706 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][N:7]2[CH:12]=[N:11][C:10]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)=[N:9][C:8]2=[O:19])=[CH:4][CH:3]=1.Cl[C:23]1[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][N:24]=1>>[Cl:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][N:7]2[CH:12]=[N:11][C:10]([N:13]3[CH2:18][CH2:17][N:16]([C:23]4[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][N:24]=4)[CH2:15][CH2:14]3)=[N:9][C:8]2=[O:19])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 923422-Chloro-5-(trifluoromethyl)pyridineHCID 117839396HCID 117839396, compound

Product 1

HCID 117839830HCID 117839830, compoundYield 3.8%

Procedure

1-(4-chlorobenzyl)-4-(piperazin-1-yl)-1,3,5-triazin-2(1H)-one (31 mg, 0.10 mmol) synthesized in Reference Synthesis Example 9 and 2-chloro-5-trifluoromethylpyridine (18 mg, 0.10 mmol) in a similar manner to Synthesis Example 76 to obtain the title compound (1.7 mg, yield: 3.7%).

Sources & evidence

ORD record
ord-97882bea76fa4f84a0b2bfec8ab44a32
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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