1-(4-Fluorophenyl)piperazine → HCID 117839181, compound

HRID 1477717Notes

Reaction equation

HRID 1477717 reaction equation
C([O:4][CH2:5][C:6]1[N:7]([CH2:15][C:16]2[S:17][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:19][CH:20]=2)[C:8](=[O:14])[N:9]=[C:10](SC)[N:11]=1)(=O)C.[F:25][C:26]1[CH:31]=[CH:30][C:29]([N:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)=[CH:28][CH:27]=1>>[F:25][C:26]1[CH:27]=[CH:28][C:29]([N:32]2[CH2:37][CH2:36][N:35]([C:10]3[N:11]=[C:6]([CH2:5][OH:4])[N:7]([CH2:15][C:16]4[S:17][C:18]([C:21]([F:22])([F:23])[F:24])=[CH:19][CH:20]=4)[C:8](=[O:14])[N:9]=3)[CH2:34][CH2:33]2)=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 752601-(4-Fluorophenyl)piperazineHCID 117839709HCID 117839709, compound

Product 1

HCID 117839181HCID 117839181, compoundYield 15%

Procedure

The synthesis was performed using [4-(methylthio)-6-oxo-1-{[5-(trifluoromethyl)thiophen-2-yl]methyl}-1,6-dihydro-1,3,5-triazin-2-yl]methyl acetate synthesized in Reference Synthesis Example 330 and 1-(4-fluorophenyl)piperazine in a similar manner to Reference Synthesis Example 348 to obtain the title compound (yield: 15%) of Synthesis Example 458a and the title compound (yield: 65%) of Synthesis Example 458b.

Workup

  1. customto obtain

Sources & evidence

ORD record
ord-d125c23ec0244c2cb5920da80a4ee8e0
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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