1-Aminopiperidine → 6-(3-Chloro-phenyl)-5-cyclopropyl-pyrazine-2-carboxylic acid piperidin-1-ylamide

HRID 1477771Notes

Reaction equation

HRID 1477771 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[N:10][C:9]=2[CH:17]2[CH2:19][CH2:18]2)[CH:5]=[CH:6][CH:7]=1.[NH2:20][N:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>>[N:21]1([NH:20][C:14]([C:12]2[CH:11]=[N:10][C:9]([CH:17]3[CH2:19][CH2:18]3)=[C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[N:13]=2)=[O:16])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 166581-AminopiperidineHCID 866823186-(3-Chloro-phenyl)-5-cyclopropyl-pyrazine-2-carboxylic acid

Product 1

HCID 715254866-(3-Chloro-phenyl)-5-cyclopropyl-pyrazine-2-carboxylic acid piperidin-1-ylamide

Procedure

The title compound was synthesized in analogy to Example 6, using 6-(3-chloro-phenyl)-5-cyclopropyl-pyrazine-2-carboxylic acid (Example 3a) and 1-amino-piperidine as starting materials, and isolated (29 mg, 40%) as white solid; LC-MS (UV peak area, ESI) 100%, 357.1485 (M+H).

Workup

  1. customisolated (29 mg, 40%) as white solid

Sources & evidence

ORD record
ord-bc3979ea73b843eb82f6a144f992ac9a
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

Loading…