Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-2-methylbutan-1-ol → 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (1-hydroxymethyl-1-methyl-propyl)-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-2-methylbutan-1-ol | HCID 10154017 | — |
| 반응물 | 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid | HCID 86682331 | — |
| 생성물 | 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (1-hydroxymethyl-1-methyl-propyl)-amide | HCID 71525575 | — |
반응 단계
The title compound was synthesized in analogy to Example 8e, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 100 mg, 0.43 mmol) and 2-amino-2-methyl-1-butanol (CAN 10196-30-2, 64.74 mg, 0.64 mmol) as starting materials, and isolated (12 mg, 8.79%) as off white solid, LC-MS (UV peak area, ESI) 100%, 320.4 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09403808B2 |
| 출처 데이터셋 | uspto-grants-2016_08 |
| ORD ID | ord-f711207597914eea929e8fbf68e8ff84 |
| 출처 메모 | uspto-grants-2016_08 |