1-Aminopiperidine → 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid piperidin-1-ylamide

HRID 1477782Notes

Reaction equation

HRID 1477782 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[NH2:18][N:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[N:19]1([NH:18][C:15]([C:7]2[CH:6]=[N:5][C:4]([CH:1]3[CH2:2][CH2:3]3)=[C:9]([O:10][CH2:11][CH:12]3[CH2:13][CH2:14]3)[N:8]=2)=[O:17])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 166581-AminopiperidineHCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 715256655-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid piperidin-1-ylamide

Procedure

The title compound was synthesized in analogy to Example 15, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 100 mg, 0.43 mmol) and 1-amino-piperidine (CAN 2213-43-6; 76.9 mg, 0.51 mmol) as starting materials, and isolated (17 mg, 12.57%) as white solid; (UV peak area, ESI) 100%, 316.6 (M+H).

Workup

  1. customisolated (17 mg, 12.57%) as white solid

Sources & evidence

ORD record
ord-b4ba1ab0ef0c41878b7e9e081e232e1e
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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