HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Aminopiperidine → 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid piperidin-1-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Aminopiperidine | HCID 16658 | — |
| Reactant | 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid | HCID 86682331 | — |
| Product | 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid piperidin-1-ylamide | HCID 71525665 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 15, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 100 mg, 0.43 mmol) and 1-amino-piperidine (CAN 2213-43-6; 76.9 mg, 0.51 mmol) as starting materials, and isolated (17 mg, 12.57%) as white solid; (UV peak area, ESI) 100%, 316.6 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09403808B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-b4ba1ab0ef0c41878b7e9e081e232e1e |
| Source note | uspto-grants-2016_08 |