Methyl L-tert-leucinate hydrochloride → HCID 71525400, compound

HRID 1477787Notes

Reaction equation

HRID 1477787 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[CH3:19][O:20][C:21](=[O:28])[C@H:22]([C:24]([CH3:27])([CH3:26])[CH3:25])[NH2:23]>>[CH3:19][O:20][C:21](=[O:28])[C@@H:22]([NH:23][C:15]([C:7]1[CH:6]=[N:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])[C:24]([CH3:27])([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 16217630Methyl L-tert-leucinate hydrochlorideHCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 71525400HCID 71525400, compound

Procedure

The title compound was synthesized in analogy to Example 6, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g) and 3-methyl-L-valine methyl ester hydrochloride (1:1) (CAN 63038-27-7) as starting materials, and isolated (98 mg, 91%) as light yellow oil; LC-MS (UV peak area, ESI) 100%, 362.2081 (M+H).

Workup

  1. customisolated (98 mg, 91%) as light yellow oil

Sources & evidence

ORD record
ord-61fd3ed9cc494992a1e92591f2b46008
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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