L-Phenylalaninamide hydrochloride → HCID 71525850, compound

HRID 1477796Notes

Reaction equation

HRID 1477796 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[NH2:19][C@@H:20]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:21]([NH2:23])=[O:22]>>[C:21]([C@@H:20]([NH:19][C:15]([C:7]1[CH:6]=[N:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)(=[O:22])[NH2:23]

Participants

3

Reactant 2

HCID 11953719L-Phenylalaninamide hydrochlorideHCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 71525850HCID 71525850, compound

Procedure

The title compound was synthesized in analogy to Example 15, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 100 mg, 0.43 mmol) and (S)-2-amino-3-phenyl-propionamide hydrochloride (1:1) (CAN 5241-58-7, 118.84 mg, 0.64 mmol) as starting materials, and isolated (60 mg, 37.03%) as colorless sticky solid; LC-MS (UV peak area, ESI) 100%, 381.4 (M+H).

Workup

  1. customisolated (60 mg, 37.03%) as colorless sticky solid

Sources & evidence

ORD record
ord-33234379f5464dafbc964238bf62c465
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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