40154-78-7 → HCID 71525945, compound

HRID 1477800Notes

Reaction equation

HRID 1477800 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[CH3:19][C@@H:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=1)[NH2:21]>>[N:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[C@@H:20]([NH:21][C:15]([C:7]1[CH:6]=[N:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])[CH3:19]

Participants

3

Reactant 2

HCID 5348723240154-78-7HCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 71525945HCID 71525945, compound

Procedure

The title compound was synthesized in analogy to Example 15, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 100 mg, 0.43 mmol) and (αS)-α-methyl-2-pyridinemethanamine hydrochloride (1:1) (100.0 mg, 0.64 mmol) as starting materials, and isolated (15 mg, 13.03%) as off white solid, LC-MS (UV peak area, ESI) 97.58%, 339.0 (M+H).

Workup

  1. customisolated (15 mg, 13.03%) as off white solid, LC-MS (UV peak area, ESI) 97.58%, 339.0 (M+H)

Sources & evidence

ORD record
ord-bc126242a9014404bf2a3f491545e45d
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

Loading…