(1S)-2,2,2-Trifluoro-1-(pyridin-2-yl)ethan-1-amine → HCID 71526034, compound

HRID 1477801Notes

Reaction equation

HRID 1477801 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[F:18][C:19]([F:29])([F:28])[C@@H:20]([NH2:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1>>[F:29][C:19]([F:18])([F:28])[C@@H:20]([NH:27][C:15]([C:7]1[CH:6]=[N:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1

Participants

3

Reactant 2

HCID 26249109(1S)-2,2,2-Trifluoro-1-(pyridin-2-yl)ethan-1-amineHCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 71526034HCID 71526034, compound

Procedure

The title compound was synthesized in analogy to Example 6, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g) and (S)-2,2,2-trifluoro-1-pyridin-2-yl-ethylamine (Example 48b) as starting materials, and isolated (71 mg, 85%) as light yellow gum; LC-MS (UV peak area, ESI) 100%, 393.1524 (M+H).

Workup

  1. customisolated (71 mg, 85%) as light yellow gum

Sources & evidence

ORD record
ord-b6ff213f498c429494fed95b5ee13154
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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