2-Amino-2-ethyl-N-methyl-butyramide → HCID 71526038, compound

HRID 1477804Notes

Reaction equation

HRID 1477804 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[NH2:18][C:19]([CH2:26][CH3:27])([CH2:24][CH3:25])[C:20]([NH:22][CH3:23])=[O:21]>>[CH2:24]([C:19]([NH:18][C:15]([C:7]1[CH:6]=[N:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])([C:20](=[O:21])[NH:22][CH3:23])[CH2:26][CH3:27])[CH3:25]

Participants

3

Reactant 2

HCID 798103702-Amino-2-ethyl-N-methyl-butyramideHCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 71526038HCID 71526038, compound

Procedure

The title compound was synthesized in analogy to Example 15, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g; 100 mg, 0.42 mmol) and 2-amino-2-ethyl-N-methyl-butyramide (78.2 mg, 0.64 mmol) as starting materials, and isolated (12 mg, 9.44%) as colorless sticky solid, LC-MS (UV peak area, ESI) 97.47%, 361.4 (M+H).

Workup

  1. customisolated (12 mg, 9.44%) as colorless sticky solid, LC-MS (UV peak area, ESI) 97.47%, 361.4 (M+H)

Sources & evidence

ORD record
ord-9378d49c7dcd4fae988edd87011e7c1c
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

Loading…