859466-62-9 → HCID 71526039, compound

HRID 1477805Notes

Reaction equation

HRID 1477805 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[CH3:18][C:19]([CH3:27])([C:21]1[S:22][CH:23]=[C:24]([CH3:26])[N:25]=1)[NH2:20]>>[CH3:18][C:19]([NH:20][C:15]([C:7]1[CH:6]=[N:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])([C:21]1[S:22][CH:23]=[C:24]([CH3:26])[N:25]=1)[CH3:27]

Participants

3

Reactant 2

HCID 28286206859466-62-9HCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 71526039HCID 71526039, compound

Procedure

The title compound was synthesized in analogy to Example 15, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g; 100 mg, 0.42 mmol) and α,α,4-trimethyl-2-thiazolemethanamine (CAN 859466-62-9, 78.2 mg, 0.64 mmol) as starting materials, and isolated (12 mg, 9.22%) as colorless sticky solid, LC-MS (UV peak area, ESI) 99.24%, 373.4 (M+H).

Workup

  1. customisolated (12 mg, 9.22%) as colorless sticky solid, LC-MS (UV peak area, ESI) 99.24%, 373.4 (M+H)

Sources & evidence

ORD record
ord-db15bbc450dc444aaf6231ec4e5391de
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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