HCID 83906267, compound → HCID 71526315, compound

HRID 1477814Notes

Reaction equation

HRID 1477814 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[CH3:18][C:19]([NH2:30])([CH3:29])[CH2:20][CH:21]([C:23]1[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=1)[CH3:22]>>[CH3:18][C:19]([NH:30][C:15]([C:7]1[CH:6]=[N:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])([CH3:29])[CH2:20][CH:21]([C:23]1[CH:24]=[CH:25][N:26]=[CH:27][CH:28]=1)[CH3:22]

Participants

3

Reactant 2

HCID 83906267HCID 83906267, compoundHCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 71526315HCID 71526315, compound

Procedure

The title compound was synthesized in analogy to Example 69, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g 10 mg, 0.043 mmol) and 1,1-dimethyl-3-pyridin-4-yl-butylamine (12 mg, 0.064 mmol) as starting materials and isolated (10 mg, 59.38%) as white solid; LC-MS (UV peak area, ESI) 99.2%, 395.2 (M+H)+.

Workup

  1. customisolated (10 mg, 59.38%) as white solid

Sources & evidence

ORD record
ord-9723ed3509f84fd994da00a5996583e2
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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