HCID 43559029, compound → HCID 71526404, compound

HRID 1477815Notes

Reaction equation

HRID 1477815 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[CH3:18][C:19]([NH2:27])([C:21]1[S:22][C:23]([CH3:26])=[CH:24][N:25]=1)[CH3:20]>>[CH3:18][C:19]([NH:27][C:15]([C:7]1[CH:6]=[N:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])([C:21]1[S:22][C:23]([CH3:26])=[CH:24][N:25]=1)[CH3:20]

Participants

3

Reactant 2

HCID 43559029HCID 43559029, compoundHCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 71526404HCID 71526404, compound

Procedure

The title compound was synthesized in analogy to Example 69, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 100 mg, 0.42 mmol) and 1-methyl-1-(5-methyl-thiazol-2-yl)-ethylamine (100 mg, 0.64 mmol) as starting materials and isolated (29 mg, 18.3%) as white solid; LC-MS (UV peak area, ESI) 94.85%, 372.8 (M+H)+.

Workup

  1. customisolated (29 mg, 18.3%) as white solid

Sources & evidence

ORD record
ord-05bb6a8ddd1f41a28577298222f97cee
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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