2-(3-Aminooxetan-3-yl)acetamide → 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (3-carbamoylmethyl-oxetan-3-yl)-amide
반응식
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[NH2:18][C:19]1([CH2:23][C:24]([NH2:26])=[O:25])[CH2:22][O:21][CH2:20]1>>[C:24]([CH2:23][C:19]1([NH:18][C:15]([C:7]2[CH:6]=[N:5][C:4]([CH:1]3[CH2:2][CH2:3]3)=[C:9]([O:10][CH2:11][CH:12]3[CH2:13][CH2:14]3)[N:8]=2)=[O:17])[CH2:22][O:21][CH2:20]1)(=[O:25])[NH2:26]참가 물질
3
실험 절차
The title compound was synthesized in analogy to Example 6 using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 50 mg, 0.21 mmol) and 2-(3-amino-oxetan-3-yl)-acetamide (31 mg, 0.24 mmol) as starting materials and isolated (30 mg, 41%) as white solid; LC-MS (UV peak area, ESI) 100%, 347.1710 (M+H)+.
후처리
- customisolated (30 mg, 41%) as white solid
출처 및 근거
- ORD 기록
- ord-3c6002cb676c4c998c3866821579aa0b
- 출처 데이터셋
- uspto-grants-2016_08
- 특허 번호
- US09403808B2
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