化工社化工社 化学情報印刷レポート · 研究参考用
2-(3-Aminooxetan-3-yl)acetamide → 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (3-carbamoylmethyl-oxetan-3-yl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(3-Aminooxetan-3-yl)acetamide | HCID 75537524 | — |
| 反応物 | 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid | HCID 86682331 | — |
| 生成物 | 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (3-carbamoylmethyl-oxetan-3-yl)-amide | HCID 86682340 | — |
反応手順
The title compound was synthesized in analogy to Example 6 using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 50 mg, 0.21 mmol) and 2-(3-amino-oxetan-3-yl)-acetamide (31 mg, 0.24 mmol) as starting materials and isolated (30 mg, 41%) as white solid; LC-MS (UV peak area, ESI) 100%, 347.1710 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09403808B2 |
| 出典データセット | uspto-grants-2016_08 |
| ORD ID | ord-3c6002cb676c4c998c3866821579aa0b |
| 出典メモ | uspto-grants-2016_08 |