HCID 19027559, compound → HCID 71526494, compound

HRID 1477818Notes

Reaction equation

HRID 1477818 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[NH2:19][CH:20]([CH:26]([CH3:28])[CH3:27])[C:21]([N:23]([CH3:25])[CH3:24])=[O:22]>>[CH3:24][N:23]([CH3:25])[C:21]([CH:20]([NH:19][C:15]([C:7]1[CH:6]=[N:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])[CH:26]([CH3:28])[CH3:27])=[O:22]

Participants

3

Reactant 2

HCID 19027559HCID 19027559, compoundHCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 71526494HCID 71526494, compound

Procedure

The title compound was synthesized in analogy to Example 69, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 80 mg, 0.34 mmol) and 2-amino-3,N,N-trimethyl-butyramide hydrochloride (CAN 1257848-66-0, 40.1 mg, 0.27 mmol) as starting materials and isolated (35 mg, 28.4%) as white solid; LC-MS (UV peak area, ESI) 93.77%, 361.0 (M+H)+.

Workup

  1. customisolated (35 mg, 28.4%) as white solid

Sources & evidence

ORD record
ord-6624661959324d22a7221b2bc1da8335
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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