4-methoxy-2-methylbutan-2-amine → HCID 71526495, compound

HRID 1477820Notes

Reaction equation

HRID 1477820 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[CH3:18][O:19][CH2:20][CH2:21][C:22]([NH2:25])([CH3:24])[CH3:23]>>[CH3:18][O:19][CH2:20][CH2:21][C:22]([NH:25][C:15]([C:7]1[CH:6]=[N:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])([CH3:24])[CH3:23]

Participants

3

Reactant 2

HCID 223449904-methoxy-2-methylbutan-2-amineHCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 71526495HCID 71526495, compound

Procedure

The title compound was synthesized in analogy to Example 69 using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 50 mg, 0.214 mmol) and 3-methoxy-1,1-dimethyl-propylamine (CAN 889765-21-3, 50 mg, 0.32 mmol) as starting materials and isolated (40 mg, 56.14%) as white solid; LC-MS (UV peak area, ESI) 99.87%, 333.8 (M+H)+.

Workup

  1. customisolated (40 mg, 56.14%) as white solid

Sources & evidence

ORD record
ord-627167c854cd4822bfbb0b656338fd9c
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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