5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid → HCID 71526580, compound

HRID 1477821Notes

Reaction equation

HRID 1477821 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[NH2:18][CH:19]([CH2:24][CH:25]1[CH2:28][CH2:27][CH2:26]1)[C:20]([NH:22][CH3:23])=[O:21]>>[CH:25]1([CH2:24][CH:19]([NH:18][C:15]([C:7]2[CH:6]=[N:5][C:4]([CH:1]3[CH2:2][CH2:3]3)=[C:9]([O:10][CH2:11][CH:12]3[CH2:13][CH2:14]3)[N:8]=2)=[O:17])[C:20](=[O:21])[NH:22][CH3:23])[CH2:26][CH2:27][CH2:28]1

Participants

3

Reactant 2

HCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acidHCID 86682341HCID 86682341, compound

Product 1

HCID 71526580HCID 71526580, compound

Procedure

The title compound was synthesized in analogy to Example 69, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 50 mg, 0.21 mmol) and 2-amino-3-cyclobutyl-N-methyl-propionamide (41.2 mg, 0.32 mmol) as starting materials and isolated (20 mg, 25.16%) as white solid; LC-MS (UV peak area, ESI) 99.32%, 373.2 (M+H)+.

Workup

  1. customisolated (20 mg, 25.16%) as white solid

Sources & evidence

ORD record
ord-0f8b655d2f1c46d4a03fc5c795700016
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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