HCID 65463282, compound → HCID 71526661, compound

HRID 1477824Notes

Reaction equation

HRID 1477824 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[NH2:18][CH:19]([CH2:22][CH:23]1[CH2:26][CH2:25][CH2:24]1)[CH2:20][OH:21]>>[CH:23]1([CH2:22][CH:19]([NH:18][C:15]([C:7]2[CH:6]=[N:5][C:4]([CH:1]3[CH2:2][CH2:3]3)=[C:9]([O:10][CH2:11][CH:12]3[CH2:13][CH2:14]3)[N:8]=2)=[O:17])[CH2:20][OH:21])[CH2:26][CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 65463282HCID 65463282, compoundHCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 71526661HCID 71526661, compound

Procedure

The title compound was synthesized in analogy to Example 69, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 50 mg, 0.21 mmol) and 2-amino-3-cyclobutyl-propan-1-ol (38.7 mg, 0.3 mmol) as starting materials and isolated (30 mg, 41%) as white solid; LC-MS (UV peak area, ESI) 99.69%, 346.2 (M+H)+.

Workup

  1. customisolated (30 mg, 41%) as white solid

Sources & evidence

ORD record
ord-4b8a035c0a22412281f527916244460c
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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