173336-86-2 → HCID 71526664, compound

HRID 1477825Notes

Reaction equation

HRID 1477825 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[NH2:19][C:20]([CH3:26])([CH3:25])[CH2:21][C:22]([NH2:24])=[O:23]>>[C:22]([CH2:21][C:20]([NH:19][C:15]([C:7]1[CH:6]=[N:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])([CH3:26])[CH3:25])(=[O:23])[NH2:24]

Participants

3

Reactant 2

HCID 75421022173336-86-2HCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 71526664HCID 71526664, compound

Procedure

The title compound was synthesized in analogy to Example 6, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 50 mg, 0.21 mmol) and 3-amino-3-methyl-butanamide hydrochloride (1:1) (CAN 173336-86-2, 35.8 mg, 0.235 mmol) as starting materials and isolated (56 mg, 79%) as light yellow solid; LC-MS (UV peak area, ESI) 100%, 333.1926 (M+H)+.

Workup

  1. customisolated (56 mg, 79%) as light yellow solid

Sources & evidence

ORD record
ord-f0a14746e0704c239097f908a8d9136e
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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