反应详情

To a solution of 1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecane (10 g, 50.69 mmol) in MeOH (100 mL) was added HCl aqueous solution (2 M, 30 mL, 60 mmol). The reaction mixture was stirred at rt overnight and then concentrated in vacuo. The residue was dissolved in water (100 mL) and adjusted to pH=8 with a saturated Na2CO3 aqueous solution, then extracted with DCM (200 mL×3). The combined organic phases were washed with brine (200 mL), dried over anhydrous Na2SO4, then filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (MeOH/DCM (v/v)=1/7) to give the title compound as a yellow solid (10 g, 100%).

1. concentrationconcentrated in vacuo
2. dissolutionThe residue was dissolved in water (100 mL)
3. extractionextracted with DCM (200 mL×3)
4. washThe combined organic phases were washed with brine (200 mL)
5. dry with materialdried over anhydrous Na2SO4
6. filtrationfiltered
7. concentrationconcentrated in vacuo
8. customThe residue was purified by silica gel column chromatography (MeOH/DCM (v/v)=1/7)