反应详情

温度

45 °C

To a solution of 2-benzyl-2-azaspiro[4.4]nonan-4-ol (10.37 g, 44.83 mmol) in MeOH (150 mL) was added Pd/C (10%, 1.1 g) and the suspension was stirred at 45° C. under a H2 atmosphere overnight. The resulting reaction mixture was filtered and the filter cake was washed with EtOAc (50 mL×3). The filtrate was concentrated in vacuo to give the product as yellow oil (7.12 g, 100%).

1. customThe resulting reaction mixture
2. filtrationwas filtered
3. washthe filter cake was washed with EtOAc (50 mL×3)
4. concentrationThe filtrate was concentrated in vacuo