2-Benzyl-2-azaspiro[4.4]nonan-4-ol → 2-Azaspiro(4.4)nonan-4-ol

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-benzyl-2-azaspiro[4.4]nonan-4-ol (10.37 g, 44.83 mmol) in MeOH (150 mL) was added Pd/C (10%, 1.1 g) and the suspension was stirred at 45° C. under a H2 atmosphere overnight. The resulting reaction mixture was filtered and the filter cake was washed with EtOAc (50 mL×3). The filtrate was concentrated in vacuo to give the product as yellow oil (7.12 g, 100%).

Provenance & Evidence