反应详情

温度

150 °C

To a solution of tert-butyl 5-((2-chloro-5-cyanopyrimidin-4-yl)amino)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate (377.2 mg, 1.037 mmol) and 1-methylpyrazol-3-amine hydrochloride (277.5 mg, 2.077 mmol) in butan-1-ol (15 mL) was added DIPEA (335.5 mg, 2.596 mmol). The mixture was stirred at 150° C. overnight, then concentrated in vacuo. The residue was purified by silica gel column chromatography (DCM/MeOH (v/v)=50/1) to give the title product as a yellow solid (425 mg, 96.56%).

1. concentrationconcentrated in vacuo
2. customThe residue was purified by silica gel column chromatography (DCM/MeOH (v/v)=50/1)