Hydrazine hydrate (1:1) → 4-Cyanobenzohydrazide

HRID 1478117Notes

Reaction equation

HRID 1478117 reaction equation
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][C:7]([C:10]#[N:11])=[CH:6][CH:5]=1.[NH2:13][NH2:14].O>CO>[C:10]([C:7]1[CH:8]=[CH:9][C:4]([C:3]([NH:13][NH2:14])=[O:2])=[CH:5][CH:6]=1)#[N:11]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 70791Methyl 4-cyanobenzoate

Product 1

HCID 4567324-Cyanobenzohydrazide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 4-cyano-benzoic acid methyl ester (1.0 g, 13 mmol) in 30 mL of MeOH was added 3 mL of H2NNH2—H2O. The mixture was stirred at ambient temperature for 16 h. The solid was collected and washed with CH3OH to give 4-cyano-benzoic acid hydrazide 9 as a solid. Yield: 0.8 g, 80%.

Workup

  1. customThe solid was collected
  2. washwashed with CH3OH

Sources & evidence

ORD record
ord-a560de19b5964701b075dd525f25dff2
Source dataset
uspto-grants-2016_08
Patent number
US09403812B2

Reaction notes

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