Hydrazine hydrate (1:1) → 4-Cyanobenzohydrazide

HRID 1478124Notes

Reaction equation

HRID 1478124 reaction equation
ClC1C=CC=CC=1N1C(C2C=CC(S(C)(=O)=O)=CN=2)=NN=C1C=CC1[O:29][C:28]([C:30]2[CH:37]=[CH:36][C:33]([C:34]#[N:35])=[CH:32][CH:31]=2)=[N:27][N:26]=1.NN.O>CO>[C:34]([C:33]1[CH:32]=[CH:31][C:30]([C:28]([NH:27][NH2:26])=[O:29])=[CH:37][CH:36]=1)#[N:35]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 67960135HCID 67960135, compound

Product 1

HCID 4567324-Cyanobenzohydrazide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 4-Cyano-benzoic acid methyl ester 1 (1.0 g, 13 mmol) in 30 mL of MeOH was added 3 mL of H2NNH2.H2O. The mixture was stirred at ambient temperature for 16 h. The solid was collected and washed with CH3OH to give 4-Cyano-benzoic acid hydrazide 2 as a solid. Yield: 0.8 g, 80%.

Workup

  1. customThe solid was collected
  2. washwashed with CH3OH

Sources & evidence

ORD record
ord-df951ff06cdc4e05afb29f58b6ff4df3
Source dataset
uspto-grants-2016_08
Patent number
US09403812B2

Reaction notes

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