Tetrabutylammonium Fluoride → HCID 118511025, compound

HRID 1478196Notes

Reaction equation

HRID 1478196 reaction equation
[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[Si]([O:26][C@@H:27]([CH3:57])[C@H:28]([C:34]1[O:38][N:37]=[C:36]([C:39]([NH:41][C:42]2[C:43](=[O:55])[N:44]([CH:49]3[CH2:54][CH2:53][CH2:52][CH2:51][CH2:50]3)[N:45]([CH3:48])[C:46]=2[CH3:47])=[O:40])[C:35]=1[CH3:56])[O:29][CH2:30][C:31]([CH3:33])=[CH2:32])(C(C)(C)C)(C)C>C1COCC1>[CH:49]1([N:44]2[C:43](=[O:55])[C:42]([NH:41][C:39]([C:36]3[C:35]([CH3:56])=[C:34]([C@H:28]([O:29][CH2:30][C:31]([CH3:33])=[CH2:32])[C@@H:27]([OH:26])[CH3:57])[O:38][N:37]=3)=[O:40])=[C:46]([CH3:47])[N:45]2[CH3:48])[CH2:54][CH2:53][CH2:52][CH2:51][CH2:50]1

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 131736504HCID 131736504, compound

Product 1

HCID 118511025HCID 118511025, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Tetrabutyl ammonium fluoride (15.16 ml, 15.16 mmol) was added dropwise to 5-((1R,2S)-2-((tert-butyldimethylsilyl)oxy)-1-((2-methylallyl)oxy)propyl)-N-(2-cyclohexyl-1,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl)-4-methylisoxazole-3-carboxamide (5.06 g, 7.58 mmol (assuming 76% purity)) in THF (160 ml) and the resulting mixture was stirred at room temperature for 18 h.

Sources & evidence

ORD record
ord-d795fac0b5454a55b6ec46be4ef47412
Source dataset
uspto-grants-2016_08
Patent number
US09403810B2

Reaction notes

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