Potassium trimethylsilanolate → HCID 118511106, compound

HRID 1478202Notes

Reaction equation

HRID 1478202 reaction equation
[C:1]([CH:5]1[CH2:9][O:8][CH:7]([C:10]2[O:14][N:13]=[C:12]([C:15]([O:17]CC)=[O:16])[C:11]=2[CH3:20])[O:6]1)([CH3:4])([CH3:3])[CH3:2].C[Si](C)(C)[O-].[K+:26]>C1COCC1>[C:1]([CH:5]1[CH2:9][O:8][CH:7]([C:10]2[O:14][N:13]=[C:12]([C:15]([O-:17])=[O:16])[C:11]=2[CH3:20])[O:6]1)([CH3:4])([CH3:3])[CH3:2].[K+:26]

Participants

4

Reactant 2

HCID 23668039Potassium trimethylsilanolateHCID 118511117Ethyl 5-(4-(tert-butyl)-1,3-dioxolan-2-yl)-4-methylisoxazole-3-carboxylate

Product 1

HCID 118511106HCID 118511106, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of ethyl 5-(4-(tert-butyl)-1,3-dioxolan-2-yl)-4-methylisoxazole-3-carboxylate (42 mg, 0.148 mmol) in THF (4 mL) was added potassium trimethylsilanolate (19.02 mg, 0.148 mmol) and the mixture was stirred at room temperature for 1.5 hours. The resulting mixture was concentrated under reduced pressure to afford the title compound.

Workup

  1. concentrationThe resulting mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-aa42dfc4fd664116bdd73a4928a94764
Source dataset
uspto-grants-2016_08
Patent number
US09403810B2

Reaction notes

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