反应详情

温度

80 °C

A solution of (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-oxobutanoate (400 mg, 1.730 mmol) in EtOAc (6.407 mL) was treated with 1-cyclobutyl-2-methylhydrazine (284 mg, 2.076 mmol) followed by sodium acetate (213 mg, 2.59 mmol). The suspension was stirred at room temperature for 30 minutes and at 80° C. for 4 hours. The resulting mixture was diluted with water (10 mL) and EtOAc was added. The layers were separated and aqueous extracted with EtOAc. The combined organic layers were washed with brine, dried over MgSO4, filtered and the solvent removed under reduced pressure. The residue was dissolved in EtOAc and iso-hexane was added. The resulting suspension was filtered and the solid rinsed with iso-hexane. The filtrate was concentrated under reduced pressure. The crude material was then adsorbed onto silica and purification by chromatography eluting with 50-100% EtOAc in iso-hexane afforded the title compound;

1. additionwas added
2. customThe layers were separated
3. extractionaqueous extracted with EtOAc
4. washThe combined organic layers were washed with brine
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. customthe solvent removed under reduced pressure
8. dissolutionThe residue was dissolved in EtOAc
9. additioniso-hexane was added
10. filtrationThe resulting suspension was filtered
11. washthe solid rinsed with iso-hexane
12. concentrationThe filtrate was concentrated under reduced pressure
13. customThe crude material was then adsorbed onto silica and purification by chromatography
14. washeluting with 50-100% EtOAc in iso-hexane