Pyrrolidine → HCID 72949310, compound

HRID 1478395Notes

Reaction equation

HRID 1478395 reaction equation
C[Si](C)(C)CCOC[N:7]1[C:11]([C:12]2[CH:30]=[CH:29][C:15]([O:16][C:17]3[CH:18]=[C:19]4[C:24](=[CH:25][CH:26]=3)[N:23]=[C:22]([CH2:27]O)[CH:21]=[CH:20]4)=[CH:14][CH:13]=2)=[CH:10][CH:9]=[N:8]1.[NH:33]1[CH2:37][CH2:36][CH2:35][CH2:34]1>>[N:8]1[NH:7][C:11]([C:12]2[CH:13]=[CH:14][C:15]([O:16][C:17]3[CH:18]=[C:19]4[C:24](=[CH:25][CH:26]=3)[N:23]=[C:22]([CH2:27][N:33]3[CH2:37][CH2:36][CH2:35][CH2:34]3)[CH:21]=[CH:20]4)=[CH:29][CH:30]=2)=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 86709313HCID 86709313, compound

Product 1

HCID 72949310HCID 72949310, compound

Procedure

The title product (243) is synthesized from intermediate E (75 mg, 0.17 mmol) and pyrrolidine according to procedure described for the synthesis of Example 250 from intermediate AU.

Workup

  1. customdescribed for the synthesis of Example 250 from intermediate AU

Sources & evidence

ORD record
ord-cc69fd67f69b42998a4aa9d66c730835
Source dataset
uspto-grants-2016_08
Patent number
US09403830B2

Reaction notes

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