HCID 114685151, compound → HCID 114686176, compound

HRID 1478481Notes

Reaction equation

HRID 1478481 reaction equation
[CH3:1][N:2]1[C:6]([CH:7]([C:9]2[N:13]([CH3:14])[CH:12]=[N:11][CH:10]=2)[OH:8])=[CH:5][N:4]=[N:3]1>O1CCOCC1.[O-2].[O-2].[Mn+4]>[CH3:1][N:2]1[C:6]([C:7]([C:9]2[N:13]([CH3:14])[CH:12]=[N:11][CH:10]=2)=[O:8])=[CH:5][N:4]=[N:3]1

Participants

4

Reactant 1

HCID 114685151HCID 114685151, compound

Product 1

HCID 114686176HCID 114686176, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 312751,4-DioxaneSolvent

Procedure

A mixture of (1-methyl-1H-1,2,3-triazol-5-yl)(1-methyl-1H-imidazol-5-yl)methanol (1.90 g, 9.83 mmol, Intermediate 6: step a) and manganese dioxide (5.04 g, 49.3 mmol) in 1,4-dioxane (100 mL) was stirred in a 100° C. oil bath under argon for 2 hours. The mixture was allowed to cool to room temperature, then was filtered through a pad of Celite®, rinsing with DCM. The filtrate was concentrated, yielding the title compound as a brown powder.

Workup

  1. filtrationwas filtered through a pad of Celite®
  2. washrinsing with DCM
  3. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-28ff627223cb4caf93a12f9b5f266a78
Source dataset
uspto-grants-2016_08
Patent number
US09403816B2

Reaction notes

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