HCID 86716094, compound → HCID 86716095, compound

HRID 1478488Notes

Reaction equation

HRID 1478488 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:12][C:13](=[O:21])[CH2:14][C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)=[C:6]([CH:11]=1)[C:7]([O:9]C)=O.CO[Na]>O1CCCC1>[Br:1][C:2]1[CH:11]=[C:6]2[C:5](=[CH:4][CH:3]=1)[NH:12][C:13](=[O:21])[CH:14]([C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1)[C:7]2=[O:9]

Participants

4

Reactant 2

HCID 86716094HCID 86716094, compoundHCID 178418582HCID 178418582, compound

Product 1

HCID 86716095HCID 86716095, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
20 °C

Procedure

Into a 100-mL round-bottom flask, was placed a solution of methyl 5-bromo-2-[2-(pyridin-3-yl)acetamido]benzoate (3 g, 7.73 mmol, Intermediate 10: step a) and MeONa (11.7 mL, 31 mmol, 2.64 M in MeOH) in tetrahydrofuran (30 mL). The resulting solution was stirred overnight at 20° C. The solids were collected by filtration and washed with water (3×5 mL). The solids were dried under vacuum to provide the title compound as a white solid.

Workup

  1. customInto a 100-mL round-bottom flask, was placed
  2. filtrationThe solids were collected by filtration
  3. washwashed with water (3×5 mL)
  4. customThe solids were dried under vacuum

Sources & evidence

ORD record
ord-99dbb87620c04119a2f1b895ee31e80e
Source dataset
uspto-grants-2016_08
Patent number
US09403816B2

Reaction notes

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