反应详情

Into a 250-mL round-bottom flask were placed a solution of 4-bromoaniline (17.1 g, 99.42 mmol) and triethylamine (30 g, 297 mmol) in dichloromethane (100 mL). Then, 2-phenylacetyl chloride (18.6 g, 120 mmol) was added dropwise with stirring, and the resulting solution was stirred at room temperature for 6 hours. The solids were filtered out, and the filtrate was concentrated under vacuum. The crude product was purified by re-crystallization from ethyl acetate to provide the title compound as a white solid.

1. customInto a 250-mL round-bottom flask were placed
2. stirringthe resulting solution was stirred at room temperature for 6 hours
3. filtrationThe solids were filtered out
4. concentrationthe filtrate was concentrated under vacuum
5. customThe crude product was purified by re-crystallization from ethyl acetate