HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Acetate → N-methoxy-6-[1-(3-pyridyl)pyrazol-4-yl]-2,3-dihydropyrano[3,2-b]pyridin-4-imine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Acetate | HCID 517044 | — |
| Reactant | O-Methylhydroxylamine hydrochloride | HCID 521874 | — |
| Reactant | 6-[1-(3-Pyridyl)pyrazol-4-yl]-2,3-dihydropyrano[3,2-b]pyridin-4-one | HCID 90043070 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-methoxy-6-[1-(3-pyridyl)pyrazol-4-yl]-2,3-dihydropyrano[3,2-b]pyridin-4-imine | HCID 123479363 | — |
Reaction Steps
6-[1-(3-Pyridyl)pyrazol-4-yl]-2,3-dihydropyrano[3,2-b]pyridin-4-one (120 mg, 0.41 mmol), CH3ONH2.HCl (38 mg, 0.82 mmol) and KOAc (81 mg, 0.82 mmol) were suspended in methanol (3 ml) under N2. The reaction mixture was refluxed overnight and purified by chromatography on silica (EtOAc) to get the title compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09403845B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-9b8230bca8e74e67a7420c294ca22398 |
| Source note | uspto-grants-2016_08 |