Trifluoroacetic acid → (S)-2-((6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)morpholine

HRID 1478558Notes

Reaction equation

HRID 1478558 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[N:12]=[C:11]3[N:13]([CH2:16][C@H:17]4[O:22][CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18]4)[N:14]=[N:15][C:10]3=[N:9][CH:8]=2)[CH:4]=[N:3]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[N:12]=[C:11]3[N:13]([CH2:16][C@H:17]4[O:22][CH2:21][CH2:20][NH:19][CH2:18]4)[N:14]=[N:15][C:10]3=[N:9][CH:8]=2)[CH:4]=[N:3]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 118364809(S)-tert-butyl 2-((6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)morpholine-4-carboxylate

Product 1

HCID 118364740(S)-2-((6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)morpholine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(S)-tert-butyl 2-((6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)morpholine-4-carboxylate (21.9 g, 54.69 mmol) was dissolved in CH2Cl2 (300 ml), and TFA (5.3 g, 82.04 mmol) was added, followed by stirring at room temperature for 2 hours. After the completion of the reaction, the reaction mixture was concentrated under reduced pressure, and the next reaction was advanced.

Workup

  1. customAfter the completion of the reaction
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. customthe next reaction

Sources & evidence

ORD record
ord-e08bd977fb8145b09175cdea6fa3e3dc
Source dataset
uspto-grants-2016_08
Patent number
US09403831B2

Reaction notes

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