Hydrochloric Acid → HCID 118364744, compound

HRID 1478561Notes

Reaction equation

HRID 1478561 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[N:12]=[C:11]3[N:13]([CH2:16][C@@H:17]4[CH2:22][N:21]([C:23]5[N:28]=[CH:27][C:26]([C:29]6[CH:30]=[N:31][N:32]([CH:34]7[CH2:39][CH2:38][N:37](C(OC(C)(C)C)=O)[CH2:36][CH2:35]7)[CH:33]=6)=[CH:25][N:24]=5)[CH2:20][CH2:19][O:18]4)[N:14]=[N:15][C:10]3=[N:9][CH:8]=2)[CH:4]=[N:3]1.[ClH:47]>C(Cl)Cl.O1CCOCC1>[ClH:47].[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[N:12]=[C:11]3[N:13]([CH2:16][C@H:17]4[O:18][CH2:19][CH2:20][N:21]([C:23]5[N:28]=[CH:27][C:26]([C:29]6[CH:30]=[N:31][N:32]([CH:34]7[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]7)[CH:33]=6)=[CH:25][N:24]=5)[CH2:22]4)[N:14]=[N:15][C:10]3=[N:9][CH:8]=2)[CH:4]=[N:3]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 118364800HCID 118364800, compound

Product 1

HCID 118364744HCID 118364744, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

(S)-tert-butyl 4-(4-(2-(2-((6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)morpholino)pyrimidin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate 463 mg (0.74 mmol) was dissolved in methylene chloride 20 ml, and 4 M HCl (excess) dissolved in 1,4-dioxane 20 ml was added and then charged with nitrogen, followed by stirring at room temperature for 18 hours. After the completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove methylene chloride and dioxane, thereby giving a yellow solid 493 mg (100%).

Workup

  1. additionwas added
  2. additioncharged with nitrogen
  3. customAfter the completion of the reaction
  4. concentrationthe reaction mixture was concentrated under reduced pressure
  5. customto remove methylene chloride and dioxane

Sources & evidence

ORD record
ord-7f5bf3dcf25a4d7d8376c4d8d6c905b9
Source dataset
uspto-grants-2016_08
Patent number
US09403831B2

Reaction notes

Loading…