反应详情

(2S)-2-((6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl)-4-(5-(1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-pyrazol-4-yl)pyrimidin-2-yl)morpholine 290 mg (0.51 mmol) was dissolved in MC 20 ml, and 4 M HCl in dioxane 2 ml was added. The mixture was stirred at room temperature overnight, and when the reaction was completed, the reaction mixture was concentrated under reduced pressure. MC and 4 M HCl in dioxane were removed, and ether was added to precipitate a solid, followed by decanting, to give a product 236 mg (89%).

1. additionwas added
2. concentrationthe reaction mixture was concentrated under reduced pressure
3. customMC and 4 M HCl in dioxane were removed
4. additionether was added
5. customto precipitate a solid
6. customby decanting