Hydrochloric Acid → HCID 118364779, compound

Participants

Reaction Steps

1-((1-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)pyrimidin-2-yl)piperidin-3-yl)methyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine (125 mg, 0.22 mmol) was dissolved in CH2Cl2 (5 ml), and then 4 N HCl dissolved in dioxane (1 ml) was added, followed by stirring at room temperature. After the reaction was completed, the reaction mixture was concentrated under reduced pressure, and then purified with ether, to give 6-(1-methyl-1H-pyrazol-4-yl)-1-((1-(5-(1,2,3,6-tetrahydropyridin-4-yl)pyrimidin-2-yl)piperidin-3-yl)methyl)-1H-[1,2,3]triazolo[4,5-b]pyrazine hydrochloride (90 mg, 82%).

Provenance & Evidence