Hydrochloric Acid → HCID 118364779, compound

HRID 1478596Notes

Reaction equation

HRID 1478596 reaction equation
C[N:2]1[CH2:7][CH:6]=[C:5]([C:8]2[CH:9]=[N:10][C:11]([N:14]3[CH2:19][CH2:18][CH2:17][CH:16]([CH2:20][N:21]4[C:25]5=[N:26][C:27]([C:30]6[CH:31]=[N:32][N:33]([CH3:35])[CH:34]=6)=[CH:28][N:29]=[C:24]5[N:23]=[N:22]4)[CH2:15]3)=[N:12][CH:13]=2)[CH2:4][CH2:3]1.[ClH:36]>C(Cl)Cl.O1CCOCC1>[ClH:36].[CH3:35][N:33]1[CH:34]=[C:30]([C:27]2[N:26]=[C:25]3[N:21]([CH2:20][CH:16]4[CH2:17][CH2:18][CH2:19][N:14]([C:11]5[N:12]=[CH:13][C:8]([C:5]6[CH2:6][CH2:7][NH:2][CH2:3][CH:4]=6)=[CH:9][N:10]=5)[CH2:15]4)[N:22]=[N:23][C:24]3=[N:29][CH:28]=2)[CH:31]=[N:32]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 118364776HCID 118364776, compound

Product 1

HCID 118364779HCID 118364779, compoundYield 82%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

1-((1-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)pyrimidin-2-yl)piperidin-3-yl)methyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine (125 mg, 0.22 mmol) was dissolved in CH2Cl2 (5 ml), and then 4 N HCl dissolved in dioxane (1 ml) was added, followed by stirring at room temperature. After the reaction was completed, the reaction mixture was concentrated under reduced pressure, and then purified with ether, to give 6-(1-methyl-1H-pyrazol-4-yl)-1-((1-(5-(1,2,3,6-tetrahydropyridin-4-yl)pyrimidin-2-yl)piperidin-3-yl)methyl)-1H-[1,2,3]triazolo[4,5-b]pyrazine hydrochloride (90 mg, 82%).

Workup

  1. additionwas added
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. custompurified with ether

Sources & evidence

ORD record
ord-0c0a6c85cbae4740a58a21325cd53055
Source dataset
uspto-grants-2016_08
Patent number
US09403831B2

Reaction notes

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