huagongshe.com
HRID1478642

反应详情

EQUATION

反应方程式

HRID 1478642 的结构方程式

REACTANTS

反应物

3
结构：[N-]=[N+]=Nc1ccc(S(N)(=O)=O)cc1
HCID3558590

未命名化合物

结构：CCC[CH2][Sn]([CH2]CCC)([CH2]CCC)[O]C(C)=O
HCID16682741

Tributyltin acetate

C14H30O2Sn

结构：C#CCNC(=O)[C@H](Cc1cscn1)NC(=O)[C@H]1O[C@@H]1C(=O)OCC
HCID71817782

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cscn1)C(=O)NCc1cn(-c2ccc(S(N)(=O)=O)cc2)nn1
HCID131736513

未命名化合物

收率 69.8%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：O=S(=O)([O-])[O-].[Cu+2]
催化剂HCID24462

Copper sulfate

CuO4S

结构：CC(C)(C)O.CCO.O
溶剂HCID86659795

未命名化合物

PROCEDURE

实验过程

The general click procedure was used substituting the following quantities using: 37 (109.0 mg, 0.31 mmol): 4-azidobenzenesulfonamide (61.5 mg, 0.31 mmol); CuSO4 (10.0 mg, 0.06 mmol); NaAsc (20.0 mg, 0.03 mmol); TBTA (10.0 mg, 0.02 mmol); in t-BuOH/EtOH/H2O (4:4:2); afforded the 42 as a white solid (119 mg, 69.8%). 1H NMR (CDCl3, 400 MHz): δ 8.93 (s, 1H); 8.45 (s, 1H); 8.39-8.05 (q, 4H); 7.33 (s, 1H); 4.83-4.77 (t, 1H); 4.57-4.48 (q, 2H); 4.28-4.23 (q, 2H); 3.64 (s, 1H); 3.50 (s, 1H); 3.40-3.21 (m, 2H); 1.28-1.23 (t, 3H). 13C NMR (MeOD-d4, 100 MHz): 170.94, 166.80, 166.72, 153.45, 151.92, 145.70, 143.49, 138.85, 127.31, 120.74, 139.76, 115.56, 61.42, 52.72, 52.67, 51, 47, 33.93, 31.91, 12.52.