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HRID1478644

反应详情

EQUATION

反应方程式

HRID 1478644 的结构方程式

REACTANTS

反应物

3
结构：[N-]=[N+]=Nc1ccc(Br)cc1
HCID75005

Benzene, 1-azido-4-bromo-

C6H4BrN3

结构：CCC[CH2][Sn]([CH2]CCC)([CH2]CCC)[O]C(C)=O
HCID16682741

Tributyltin acetate

C14H30O2Sn

结构：C#CCNC(=O)[C@H](Cc1cscn1)NC(=O)[C@H]1O[C@@H]1C(=O)OCC
HCID71817782

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cscn1)C(=O)NCc1cn(-c2ccc(Br)cc2)nn1
HCID131736515

未命名化合物

收率 42.8%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：O=S(=O)([O-])[O-].[Cu+2]
催化剂HCID24462

Copper sulfate

CuO4S

结构：CC(C)(C)O.CCO.O
溶剂HCID86659795

未命名化合物

PROCEDURE

实验过程

The general click procedure was used substituting the following quantities using: 37 (60 mg, 0.17 mmol); 1-azido-4-bromobenzene (51 mg, 0.26 mmol); CuSO4 (4.4 mg, 0.03 mmol); NaAsc (22 mg, 0.11 mmol); TBTA (20.0 mg, 0.04 mmol); in t-BuOH/EtOH/H2O (2:2:1); afforded the 44 as a white solid (40 mg, 42.6%). 1H NMR (DMSO-d6, 400 MHz): δ 9.00-8.99 (d, 1H, J=1.66 Hz); 8.74-8.71 (t, 1H); 8.63-8.61 (d, 1H, J=8.22 Hz); 8.54 (s, 1H); 7.60-7.56 (d, 2H, J=14.85 Hz); 7.345-7.341 (d, 1H, J=1.63 Hz); 7.11-7.07 (d, 2H, J=14.85 Hz); 4.69-4.66 (q, 1H); 4.40-4.38 (d, 2H, J=5.59 Hz); 4.20-4.13 (m, 2H); 3.66-3.66 (d, 1H, J=1.73 Hz); 3.52-3.51 (d, 1H, J=1.73 Hz); 3.33-3.12 (m, 2H); 1.23-1.20 (t, 3H). 13C NMR (100 MHz, DMSO-d6): 170.57, 167.51, 165.36, 154.07, 153.27, 146.56, 139.39, 136.25, 122.30, 121.54, 117.51, 116.23, 61.97, 53.46, 52.99, 51.76, 34.75, 33.50, 14.32.